Tetracyclic Condensed Pyrimidines. New Derivatives of the Benzo [4’,5’] Imidazo [2’,1’:6,1] Pyrido [2,3-D] Pyrimidines
نویسندگان
چکیده
منابع مشابه
Expanding the scope of fused pyrimidines as kinase inhibitor scaffolds: synthesis and modification of pyrido[3,4-d]pyrimidines.
Fused pyrimidine cores are privileged kinase scaffolds, yet few examples of the 2-amino-pyrido[3,4-d]pyrimidine chemotype have been disclosed in the context of kinase inhibitor programs. Furthermore, no general synthetic route has been reported to access 2-amino-pyrido[3,4-d]pyrimidine derivatives. Here we report a versatile and efficient chemical approach to this class of molecules. Our strate...
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Bronchial asthma is a chronic debilitating disease, which in its severe forms can even threaten life. It is, in general, characterized by both broncho-constriction and airway inflammation which leads to bronchial hyper responsiveness [1]. Although different classes of drugs have been employed, methylxanthines continue to enjoy significant status as drugs of choice in asthma therapy, despite a n...
متن کاملSynthesis and Antimicrobial Activity of Some Novel Benzo Thieno Pyrimidines
Cyclization and chlorination of 2-amino-5-benzyl-4, 5, 6, 7-tetrahydro hydro thieno [3, 2c] pyridine-3carboxamide yielded (3 a-b). Reaction with different substituted pyridines of [3 a-b] yielded 4a (1-4) and 4b (1-2). However reaction of 3a with different substituted 2-amino phenols yielded 4a (5-6). Further 3a yields 4a (7) & 4a (8) from different substituents like o-phenylene diamine and 4-c...
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The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Oth...
متن کاملQSAR analysis of 2,4-diaminopyrido[2,3-d]pyrimidines and 2,4-diaminopyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
Dihydrofolate reductase (DHFR) plays a ubiquitous role in the biosynthesis of DNA, RNA and essential amino acid methionine, and exhibits potential application in the treatment and prophylaxis of AIDS-associated opportunistic microbial infections. In this study, a series of DHFR analogs of 2,4-diaminopyrido[2,3-d]pyrimidines and 2,4-diaminopyrrolo[2,3-d]pyrimidines were subjected to quantitative...
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ژورنال
عنوان ژورنال: American Journal of Biomedical Science & Research
سال: 2020
ISSN: 2642-1747
DOI: 10.34297/ajbsr.2020.07.001201